COMPUTER AIDED DRUG DESIGN: A MINI-REVIEW

Barrawaz Aateka Y*, Shahajan S Baig, Bawazir Abubakar Salam

Y. B. Chavan College of Pharmacy, Aurangabad, Maharastra, India

ABSTRACT

New drug discovery and development process is considered much complex process which is time consuming and resources accommodating too. So computer aided drug design are being broadly used to enhance the effectiveness of the drug discovery and development process which ultimately saves time and resources. Various approaches to Computer aided drug design are evaluated to shows potential techniques in accordance with their needs. Two approaches are considered to designing of drug first one is structure-based and second one is Ligand based drug designs. In this review, we are discussing about highly effective and powerful techniques for drug discovery and development as well as various methods of Computer aided drug design like molecular docking at virtual screening for lead identification, QSAR, molecular homology, de-novo design, molecular modeling and optimization. It also elaborate about different software used in Computer aided drug design, different application of Computer aided drug design etc. Major objectives of Computer aided drug design are to commence collaborative foundation of research activities and to discover new chemical entities for novel therapeutics drugs

Keywords:

QSAR, molecular modeling, Computational optimization, receptor and ligand, Drug designing