MOLECULAR DOCKING ANALYSIS OF NATRIURETIC PEPTIDE RECEPTOR-C TOWARDS THE DESIGN OF POTENTIAL ATRIAL FIBRILLATION INHIBITORS

Shubhda Dev*, Bashah J Khan

Amity University, Noida, NCR, India

ABSTRACT

Atrial fibrillation (AF) stands the most widely recognized kind of clinical arrhythmia. Right now accessible anti-Atrial Fibrillation drugs are restricted by just moderate adequacy and an unfavorable safety profile. There is a perceived requirement for enhanced antiarrhythmic agents including activities that are specific for the fibrillating atrium. Therefore, it is of interest to design an appropriate medication for the disease Atrial Fibrillation using Molecular Docking techniques through protein-ligand interaction analysis. Hence, we document the Molecular docking analysis of natriuretic peptide receptor-C towards the design of potential Atrial Fibrillation inhibitors (Aprindine, Inclacumab, and Budiodarone) with the most favorable binding features for further consideration. This study centers around the process for drug discovery finding appropriate medication for the disease Atrial Fibrillation by Molecular Docking technique through protein-ligand interaction. The examination uncovered that out of a couple of molecules that were chosen as target, three of them were seen as most reasonable having the least energies compared to the other molecules. Aprindine, which is utilized in arrhythmia patients as a cardiac depressant. Inclacumab, which is an investigational sedate utilized in trials to look at the treatment and evasion of Myocardial Infarction, Peripheral Arterial Disease (PAD), and Coronary Heart Disease. Budiodarone, which is an antiarrhythmic drug at present in clinical preliminaries identified with amiodarone.

Keywords:

Atrial Fibrillation, Molecular Docking, Molegro Virtual Docker, Drug Discovery, Protein-Ligand Interaction