A REVIEW ON FAST DISSOLVING TABLETS

Jyoti Saxena*, Digvijay Singh, Amrita Bisht, Arvind Negi, Aman Verma

GRD Institution of Management & Technology (Pharmacy), Dehradun, Uttarakhand, India

ABSTRACT

As we are aware of the fact that Fast dissolving tablets have made an appearance as one of the most greatly welcomed dosage form, exceptionally between the pediatric patients and also among the geriatric patients, as both the category of patients have weaker muscular and the nervous system in comparison to adults as well as struggle to consume tablets and capsules. In the case of geriatric patients, Parkinson’s disorder and hand tremors are a major concern and Fast dissolving tablet is one of the most convenient dosage forms. The oral route is considered one of the best-preferred route to administer the drug in animal body but it also has few limitations too. For example, drugs have to go through first-pass metabolism, not preferred in psychiatric and bedridden patients. The FDTs are structured in a way to dissolve very quickly in saliva and this is the most celebrated property of FDTs, that these tablets disintegrate or dissolve in saliva in less than a minute and this process does not need water. Superdisintegrants like Crosscarmellose Sodium and Sodium Starch Glycolate are the backbones of the FDTs, which amplify the rate of disintegration of tablets inside the buccal cavity, results in faster absorption and finally improved bioavailability. There are a number of advantages are offered by FDTs which includes trouble-free transportation and manufacturing, error-free dose, remarkable physical and chemical stability, and above all, its acceptance among pediatrics and geriatric patients. FDTs provide the benefits of both the conventional tablets as well as of liquid dosage forms. FDTs can be manufactured by a number of conventional and patented technologies such as melt granulation, sublimation, direct compression freeze-drying or lyophilization, cotton candy process, etc. These techniques yield the rapid disintegration of tablets which dissolve in the buccal cavity in five seconds and do not need water and chewing. This review includes the definition, needs, advantages, and limitations, challenges to formulate and to manufacture the FDTs, and also some formulations of fast dissolving tablets which are available in market.

Keywords:

Fast Dissolving Tablet, drug delivery system, rapid disintegrating, fast melting