FORMULATION DEVELOPMENT AND EVALUATION OF NIOSOMAL GEL OF TAZAROTENE FOR TREATMENT OF PSORIASIS

Dr. Vivek Jain, Raghuraj Lovanshi*, Anwar Iqbal Khan

NRI Institute of Pharmacy, Bhopal, Madhya Pradesh, India

ABSTRACT

Aim of the current work was to prepare and characterize Tazarotene encapsulated niosome, incorporated in to a appropriate dermatological base and assess its comparative effectiveness in the cure of dermal infections. Drug encapsulated niosomes was formulated by thin film hydration method using different ratio of drug, cholesterol and surfactant ratio. Vesicular carriers were characterized for vesicle shape and size, drug entrapment efficiency, and in-vitro diffusion study. Vesicular size, zeta potential and drug entrapment efficiency of the optimized niosomes were determined. Microscopic examination suggests niosomes to be multilamellar vesicles with smooth surface. In-vitro diffusion study demonstrated that the drug diffused from optimized batch (F1) niosomal gel was found 95.69%. Optimized formulations were subjected for stability studies carried out at 4.0ºC ± 0.5 ºC and 28 ± 0.5ºC for 28 days. There was no important variation found in physical appearance, average particle size and % drug content of niosomes gel.

Keywords:

Niosome, Gel, Tazarotene, Psoriasis, In-vitro diffusion