FORMULATION AND IN-VITRO EVALUATION OF NIOSOMAL GEL OF GATIFLOXACIN

Dr. Vivek Jain, Deepak Rai*, Anwar Iqbal Khan

NRI Institute of Pharmacy, Bhopal, Madhya Pradesh, India

ABSTRACT

A novel drug delivery system provides the delivery of drugs at a required rate into the body during the period of treatment as directed by the body. Formulation and evaluation of Noisome containing gatifloxacin using different concentrations of the polymer for controlled release. Pre-formulation study confirms the purity of the drug and compatibility of the drug with excipients using FT-IR. Tween 80 was found significant with the experimental results. An extensive investigation is needed concerning the depth of penetration into the skin, determination of zeta potential, and confirmation of configuration of phospholipids in the lipid bilayer. A significant loss of entrapped drug was found at the end of three month period when liposomal dispersions were stored at high temperature i.e. 25±20C. All gels were found under pH range 7.0 to 7.4, Spreadability under the range 6.6 to 7.6 cm, % drug content 98 to 100%, the viscosity of gels 98 to 115cp, and % permeation found in rage 75 to 91%. Excellent % Permeation Gel formulation GF-4 was found 91%. The drug release at raised temperatures may be associated with the lipid degradation in the bilayers results in membrane packing defects them leaky.

Keywords:

Gatifloxacin, Noisome, Gel, lipophilic nature, entrapped drug