ANTHELMINTIC, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF DIFFERENT PART OF INDIAN ORIGIN SALVADORA PERSICA

Dharmendra Kumar*, Pramod Kumar Sharma

School of Medical and Allied Science, Galgotias University, Gautam Buddh Nagar, Uttar Pradesh, India

ABSTRACT

Nowadays, Herbal products are attracting the whole population of the world because of their safety features. The present study aimed to reveal the phytochemical compositions, anthelmintic activity, antioxidant and antimicrobial potential of Salvadora persica leaves extract in different extraction solvent systems. Shade dried leaves of Salvadora persica were extracted in chloroform, ethyl acetate, methanol, ethanol, and water using the modified fractional maceration method. These extracts were analyzed for their phytochemical, anthelmintic activity, antioxidant and antimicrobial potential. The antioxidant activity was done using DPPH and H2O2 radical scavenging method. While the antimicrobial potential was analyzed using the disc diffusion method. Anthelmintic activity was determined against Indian earthworms (Eiseniafetida).The highest percentage yield of extract was found in the hydro solvent extraction system. The DPPH radical scavenging was found 67.3% (lowest) and 99.07% (highest), (dose100µg/ml), in SPLEC and SPLEW respectively. The highest antimicrobial activity was found in SPLEE (200µg/ml and 100µg/ml) i.e. 6 mm and 4 mm zone of inhibition against E.coli while 5mm and 3mm again B. subitilis respectively. All extract fractions of Salvadora persica exhibited anthelmintic activity but less than standard drug albendazole. Based on our findings, we were concluded that leaves of Salvadora persica have an anthelmintic effect good antioxidant and antimicrobial potential so their consumption may exert a beneficial effect on human and animal health as well

Keywords:

Salvadora persica; Antioxidant; Antimicrobial; Anthelmintic; ? max validation; extract