PHARMACOLOGICAL ASSESSMENT OF ANTIULCER ACTIVITY OF GLORIOSA SUPERBA LINN TUBERS IN EXPERIMENTALLY INDUCED GASTRIC ULCERS

Vaibhav P Uplanchiwar*, Sushil Yadaorao Raut, Sachin M Hiradeve, Lalchand D Devhare, Suhas N Sakarkar, Vijendra B Fulzele, Mohammad Hashim Mansoori

G H Raisoni University, Sausar, Chhindwara, Madhya Pradesh, India

ABSTRACT

In a study, the potential of hydroalcoholic and petroleum ether extract of Gloriosa superba Linn (GS) tubers in the mitigation of antisecretory and antiulcer was studied. Both extracts were tested at 100, 200, and 400 mg/kg/p.o. using ethanol, and cold stress as toxicants. Both the extracts showed significant ulcer protection at the highest dose of 400mg/kg as compared to standard drug lansoprazole. To support its antiulcer potential, the plant was examined for radical - scavenging capability by lipid peroxidation. The extracts showed a comparative significant result. The flavonoids & polyphenols in the extracts verify the antioxidant potential. From the results, it was concluded that both hydroalcoholic and petroleum ether extracts of tubers of Gloriosa superba are having gastric ulcer protective activity.

Keywords:

Gloriosa superba; Colchicaceae; Antiulcer; Ethanol, cold stress