Employing antimicrobial nanoparticles to reduce oral biofilms

Shakti Rath*, Debasmita Dubey, Swaraj Kumar Babu, Snigdha Pattanaik

Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

ABSTRACT

Oral biofilm is a major problem in almost all individuals as they cause dysbiosis of the oral cavity and lead to various microbial infections and related ailments. Currently, antibiotics and antifungal drugs are the major way to control oral biofilm, but the rapid increase in antibiotic-resistant bacterial strains has limited the treatment options and increased the virulence factors of these bacteria. With the inception of nanotechnology, metals such as gold, silver, copper and titanium can be converted to nanoparticles, which are target-oriented particles with enhanced therapeutic values and antimicrobial efficacy with minimum side effects. The application of nanoparticles in antimicrobial drugs increases in potential, as a function of their biocidal, anti-adhesive, and delivery capabilities, shows much potential.

Keywords:

Oral Biofilm, Nanoparticles, Antimicrobial Efficacy, Target Specific