Aqueous extract of whole plant of hyptis suaveolens (l.) poit: An anti-ulcer agent

Yada Deepthi*, T Sivakkumar, Nimmagadda Srinivas

Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad, Hyderabad, India

ABSTRACT

The aim of current experimental study was to determine anti-ulcer potential of Watery extricate of Hyptis suaveolens entire plant (AEHS) on the Wister strain albino rats. The Watery extricate of Hyptis suaveolens entire plant (in two different doses, 250mg/kg and 500 mg/kg) was allowed for anti-ulcer activity against Pylorus ligation induced model in Wistar albino rats. Omeprazole (20mg/kg) was used as standard for the evaluation of activity. Parameters like Proportion of Ulcer protection was reckoned based on Ulcer index and Digestive juice volume, pH and acidity of gastric juice, Mucus production and Pepsin estimation, tensile strength. The AEHS with 500 mg/kg dose was shown significant anti-ulcer activity when compared with the control group.

Keywords:

Hyptis suaveolens Omeprazole, Ulcer index, Ulcer protection, Free acidity, Total acidity