Methodical insights into reported sophisticated analytical techniques for the determination of anti-diabetic drug empagliflozin in various pharmaceutical products

Manjiri Gundle, Kishor Danao*, Ruchi Shivhare, Vijayshri Rokde, Amol Warokar, Debarshi Mahapatra

Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India

ABSTRACT

Empagliflozin (EMPA), chemically known as (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol is an oral anti-diabetic drug used for treating type 2 diabetes mellitus that produces hypoglycemia by selective and competitive inhibition of sodium/glucose co-transporter-2 (SGLT2) protein. Currently, EMPA is an emerging drug being prescribed by medical practitioners. The quality-oriented scheduled investigation of diverse commercially obtainable formulations of EMPA is a foremost challenge and recently few sophisticated analytical methods are reported for industrial-scale quantitative analysis. Review of analytical method of antidiabetic drug Empagliflozin. This interesting review article covered the recently published sophisticated instruments-based analytical methods in numerous pharmaceutical databases like PubMed, Google Scholar, Science Direct, etc. of diverse areas like spectrophotometry (Ultraviolet-Visible), Ultra-high Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), High-Performance Thin Layer Chromatography (HPTLC), and analytical methods for estimation of EPMA in human plasma. From literature, about 19 HPLC methods, 4 UPLC methods, 15 UV-Vis methods, 3 HPTLC methods, and 4 human plasma-based methods were reported for the estimation of EMPA alone or in combination with other drug substances (Linagliptin, Canagliflozin, Dapagliflozin, and Metformin). The methodical insights outlined the reported characteristics like method, detection wavelength, solvent, % recovery, LOD, LOQ, mobile phase composition, flow-rate, column type, retention time, etc. This review concluded that the developed validated analytical methods have a high degree of accuracy, superior reliability, economical to apply, bears good precision, possess better robustness, and greater reproducible attributes which are compulsory features of an ideal method.

Keywords:

Empagliflozin, Estimation, Analysis, Quantitative, Formulation, Determination