Synthesis and molecular docking analysis of oxazetidine derivatives for neurological disorders

Lonikar N.B., Sangshetti J.N., Bhusnure O.G.*

Channabasweshwar Pharmacy College, Latur, Maharastra, India

ABSTRACT

A series of Oxazetidine (NL1-NL12) from reacting tryptophan and aromatic aldehydes were synthesized in good yields by involving 2-{[(4-chlorophenyl) methylidene] amino}-3-(1H-indol-3-yl) propanoic acid and chloro acetyl chloride as reactive intermediates. All the synthesized derivatives were screened via spectral techniques. Synthesized molecules were virtually screened against Human A2A Adenosine receptor interactions analysis using molecular docking to elucidate CNS potential. Synthesized derivatives showed excellent binding towards the Human A2A Adenosine receptor.

Keywords:

Oxazetidine, Human A2A Adenosine receptor, Docking, CNS