An insight of covid-19 and Mucormycosis

Dubey Neha, Yadav Ramakant, Dubey Gaurav*, Pant Kamal, Singh Arvind, Chandra Mahesh, Ali Jamshed, Pradhan Nitesh, Saharan Kumar Ajeet, Kumari Ragni

Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

ABSTRACT

Mucormycosis is an infrequent infectious disease engendered by Mucorales fungi that primarily affects COVID-19-positive patients in India. Corticosteroids are frequently used to treat COVID-19. Corticosteroids vanquish the body’s immune response and raise blood sugar levels in diabetic COVID-positive patients and are often found with the Rhino-orbital cerebral Mucormycosis. Neutropenia, solid organ, and stem cell grafting, excessive intake of iron, and deferoxamine therapy are associated risk factors. The saprophytic fungus initially attacks the sinuses before spreading to the oral cavity, lungs, and eye orbit, causing an acute phase of inadequate blood supply to the tissue which finally led to Necrosis. If left untreated, it can result in temporary or permanent loss of vision, fever, headache, reddened and swollen skin near the nose or eyes, facial pain, and eventually death. Laboratory parameters, tissue biopsy, CT scan, and reverse transcriptase-polymerase chain reaction are few investigations. Amphotericin B and Micafungin are the commonest advisable anti-fungal medication. Surgical debridement or removal of contaminated tissue, particularly in infections of the rhino-orbito-cerebral, cutaneous, and gastrointestinal Mucormycosis, is required.

Keywords:

Clinical Parameters, COVID-19, Mucormycosis, risk factors, laboratory