To establish the correlation between p53 and histopathological grading of glial tumors

Dr. Tabish Hassan*, Dr. Samarth Shukla, Dr. Shourya Acharya, Dr. Sunita Vagha, Dr. Anita Sajjanar

Jawaharlal Nehru Medical College, Maharashtra, India

ABSTRACT

Glial tumors occupy approximately 70% of the spectrum of all brain tumors with astrocytoma’s being the most common primary. High grade glial tumors have a poor outcome with limited survival rate. To establish the correlation between p53 status and histological grading of glial tumors. Objectives: To diagnose glial tumors on histopathological examination, to evaluate histological grade, to evaluate p53 expression and to assess the correlation between p53 expression and histological grade of gliomas. The study investigated 52 cases of gliomas. Histological grade was determined by WHO Grading System. Nuclear expression of p53 was evaluated by immunohistochemistry. A direct correlation between the histological grade and the p53 expression was observed. High grade gliomas exhibit high p53 expression. Thus, p53 as an adjunct to histological grade can provide a supportive clue to the clinicians, to predict the biological behaviour of gliomas.

Keywords:

Glial tumors, p53, Immunohistochemistry