Anxiolytic, antidepressant and anticonvulsant activity of mucuna pruriens seeds

Patil Rupali A.*, Ahmad Azharuddin I

Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Vidyanagar, Nashik, Maharashtra, India

ABSTRACT

Behavioral models such as the elevated plus maze (EPM), light and dark method, Hole-board method, and Marble burying method were used to assess Methanolic extract of Mucuna pruriens seeds (MEMP) for anxiolytic function. MEMP in a dose of 200 and 300 mg/kg, p.o. was found to possess significant anxiolytic activity. In TST and FST, MEMP showed a substantial reduction in the time of immobility, indicating antidepressant action. MEMP significantly increased the latency for straub tail, extensor, myoclonic jerk, clonic convulsion and stupor in pentylenetetrazol (PTZ) and isoniazid-induced convulsion models. MEMP may be interfering with the level of monoamines; L-dopa, serotonin and histamine and produced antidepressant activity.

Keywords:

anxiolytic, convulsion, depression, Elevated plus maze, Forced swim method, Pentylenetetrazol, Tail suspension method