Formulation, development and optimisation of pH. dependent drug delivery system containing proton pump inhibitor

Ghugarkar Prasad Gorakshanath*, Khulbe Preeti

Suresh Gyan Vihar University, Jaipur, India

ABSTRACT

The present study was involving the targeting the Rabeprazole formulation at site specificity. Peptic ulcer mostly occurs in the lower part of the gastrointestinal tract. Proton pump inhibitors category drugs mainly used to cure peptic ulcer. As most of proton pump inhibitors degrades in acidic condition in stomach, the present study mainly focus on targeting site specificity without degradation of drug in stomach. Rabeprazole and selected excipients was tested for reformulation study as well as for analytical techniques like Ultra Violet Visible Spectroscopy, Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. Core pellet formulation of Rabeprazole was formulated using extruder and spheroniser. After core pellet preformulation seal coating of pellet was completed. As seal coating mainly helps the core pellet from interaction between another coating polymer. Seal coating was completed by using Opadry coat. At the top of the pellet polymer coat was applied. Polymer coat was helps to deliver the formulation in appropriate pH only. Polymer coat also protects the formulation from degradation in stomach where acidic condition presents. Evaluation parameters like dissolution test, Ultra Violet Visible Spectroscopy, Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry, optimisation parameter applied to optimised formulation. Stability study was performed on optimised formulation.

Keywords:

Ulcer, Gastrointestinal tract, Polymer, Coating.