The systemic study of various vaccines in term of current status of clinical trial, Safety and effectiveness of covid vaccine

Warude B J, Bamb Y R*, Bamb P R, Walode S.G, S.N Wagh

Rasiklal M. Dhariwal Institute of Pharmaceutical Education & Research, Pune, Maharashtra, India

ABSTRACT

Industries leading the experiment and clinical trial of various vaccines to approve effectiveness and safety on humans. Several of them were documentation for a patent, authorization of clinical trial and marketing. In the review study, we provide an overview of Covid-19, types of vaccine and mechanism of action. Consider the reference of the mechanism of actions such as an inactivated vaccine, vector vaccines, DNA and RNA based vaccine and antiviral drugs already entered in (Phase II and III) clinical trials. The systemic study quantified a summary of various vaccines in the form of the present status of clinical trial, safety and effectiveness according to ICH E6 (R2) guidelines. Due to leading adverse interaction with their toxicity study, the inventor may face challenges during the post-marketing clinical trial. The genuine information allows upcoming scientists to improve the quality, and minimize the adverse effects and avoid resistance power for developing newer drugs.

Keywords:

SARS-CoV-2 DNA and RNA based vaccine, vector vaccines and clinical trial