In-vitro antifungal study of various solvent extracts of costus specious (j. Koenig) sm. and costus pictus d. don against candida species

Shaikh Sana S*, Abubakar SB, Barrawaz Aateka Y, Dehghan MH, Mohammad Abdul J

Y B Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra, India

ABSTRACT

The present investigation includes evaluation of various solvent extracts of Costus specious (J. Koenig) Sm. and Costus pictus D. Don. for in-vitro antifungal activity against selected Candida strains. The selected plants belong to the family Costaceae. Solvents such as hexane, methanol, water, and ethyl acetate of Costus pictus and standard extract of Costus specious were evaluated against Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Candida krusei. The susceptibility of the fungal strains against the extracts was assessed by the agar well diffusion method. Clotrimazole was used as a positive control. The zone of inhibition was determined for each extract in comparison with the positive control. Results were recorded after 72 h. Of the various extracts analyzed, the hexane extract exhibited a potential antifungal activity overall. The methanolic, ethyl acetate extract of Costus pictus and standard extract of Costus specious shows some degree of activity against C. glabrata and C. parapsilosis. The aqueous extract shows no antifungal activity against the selected fungal strains. The above study indicates that C. krusei was more resistant to the solvent extracts; however, C. albicans and C. glabrata were more susceptible. Hence, Costus specious (J. Koenig) Sm. and Costus pictus D. Don demonstrate promising antifungal potential.

Keywords:

Antifungal, Costaceae, Candida, Costus specious, Costus pictus.