Formulation and In Vitro Evaluation of Mucoadhesive Buccal Tablet of Lafutidine

Dattatraya M Shinkar, Bharati D Aher, Parag D Kothawade, Santosh S Surana, Prashant L Pingale

Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research Nashik, Maharashtra, India.

ABSTRACT

The mucoadhesive buccal tablet of lafutidine was formulated to overcome the problem of low bioavailability. All the tablet formulations compressed by direct compression technique using xanthan gum and guar gum. In vitro drug release profiles and release kinetics of all tablet formulations were analyzed; % swelling index and mucoadhesive strength were determined. Formulation F6 optimized formulation consist of 20 % xanthan gum and 10 % guar gum, which provided 98.66±0.96% drug release at 12 h and higher mucoadhesive strength. FTIR spectroscopy studies shown that there was interaction between the drug and excipients selected. Lafutidine was released more than 90�ter 12 h of in vitro drug release studies, supported by swelling and matrix erosion investigation. The drug was released by anomalous (non-Fickian) mechanism have release exponent (n) value of 0.79, indicating combined erosion and swelling and fitted best to zero-order model. The study concluded that a buccal tablets of lafutidine containing xanthan gum and guar gum showed a promising potential alternative as a mucoadhesive drug delivery system for the treatment of peptic ulcer.

Keywords:

Mucoadhesive buccal tablet, Lafutidine, Polymers, Bioavailability