Formulation and development of poly-herbal lozenges: a solace for mouth ulcer

Harak Shilpa, Sharma Roma, Sonawane Amruta, Thakur Sonia

GES's Sir Dr. M.S. Gosavi College of Pharmaceutical Education & Research, Nashik, Maharashtra, India

ABSTRACT

Mouth ulcers are the most prevalent lesions of oral mucous which are painful and part of a recurrent inflammatory process. Mouth ulcers most frequently occur due to deficiency of vitamin B12 and zinc, as a secondary effect of a bacterial infection, or due to increased body heat and inflammation. Mechanical causes include tongue bites and ill-fit dentures. The goal of this research is to minimize the pain and healing time of ulcers using a polyherbal combination compounded in form of lozenges. Piper betle L. leaves have been discovered in a broad range of activities like anti-inflammatory, antiulcer, antifungal, antibacterial, digestive, and antioxidant. Honey possesses excellent antiulcer activity. In addition, the presence of Psidium guajava leaves (zinc source), clove oil (local anesthetic to effect in the swollen oral cavity), gulkand (smoothening), and mint (flavor) enhances the organoleptic as well as the medicinal value of the lozenges. The lozenges were prepared using the hand roll method. The lozenges also were evaluated for physicochemical properties such as friability, weight uniformity, and dissolution time.

Keywords:

Polyherbal Lozenges, Honey, mouth ulcer, Piper Betle, Medicated lozenges