Formulation and Evaluation of Pirfenidone Sustained Release Matrix Tablets

Bhushan R Rane, Krushna P Damale, Ashish S Jain, Prashant L Pingale, Nayan A Gujarathi

Shri DD Vispute College of Pharmacy and Research Centre, Panvel, India

ABSTRACT

The goal of this study was to create a Pirfenidone sustained release matrix tablet, which is an anti-fibrotic drug. Pirfenidone is a drug that is used to treat idiopathic pulmonary fibrosis (IPF). The direct compression method was used to make the sustained release tablets. As release retarding polymers, ethyl cellulose, methyl cellulose, and HPMC were utilized. To find the best formulation, different batches (F1 to F9) were made by varying the drug polymer ratio. The FTIR peak matching technique was used to investigate the drug's compatibility with other excipients, and the substances were determined to be compatible. Angle of repose, Carr's index, Hausner's ratio, bulk density, and tapped density were all evaluated prior to compression, and the granules demonstrated the best flow qualities. Weight variation, drug content, hardness, friability, and invitro dissolution investigations were all performed on the compressed tablets, and all of the formulations passed the tests. The results of dissolution studies revealed that formulation F8 could extend the release for up to 8 hours, making it the most successful formulation in the study. It was expected to improve patient compliance while reducing administration frequency and side effects by avoiding the sudden burst release.

Keywords:

Pirfenidone, HPMC, Methyl cellulose, Ethyl Cellulose, Matrix tablets, Direct compression