Formulation and evaluation of antifungal hair gel containing hydroalcoholic extract of fagonia schweinfurthii hadidi

Dinesh Puri, Praveen Kumar Gaur, Alok Pratap Singh, Monika Singh, Mohd. Yasir, Sanjay Kumar

Graphic Era Hill University, Dehradun, Uttarakhand, India

ABSTRACT

Nature is one the major source of drugs in medical field. The whole plant or a part of plant and its extract can be used to treat number of diseases in human. Fagonia schweinfurthii hadidi is herb found in desert which has great medicinal values. The aim of this study was to find the antifungal activity of Hydroalcoholic extract of Fagonia schweinfurthii hadidi and formulate herbal cream. In this study Hydroalcoholic extract of Fagonia schweinfurthii hadidi used as antifungal agent. Antifungal study was carried out by determination of minimum inhibitory concentration (MIC) and zone of inhibition against Candida albicans and Malassezia furfur. Nine formulations were prepared using factorial design. Aloe Vera, Carbopol 934, HPMC, PEG, Methyl paraben and Triethanolamine were used to prepare gel formulation. MIC against C. albicans and M. furfur was found to be 100 μg/ml and 90 μg/ml respectively while zone of inhibition was found to be 39 ± 1.7 mm and 42± 1.2 mm respectively of Hydroalcoholic extract of F. schweinfurthii hadidi. Viscosity, spreading coefficient and pH of optimized F5 formulation were found to be 14453±32 cp, 23.89±6 gm.cm/sec and 6.9 respectively. Zone of inhibition shows that it has optimum antifungal activity against C. albicans (35 ± 1.2 mm) and M. furfur (40± 1.4 mm). Antifungal study reveals that F5 formulation had potent antifungal activity against C. albicans and M. furfur.

Keywords:

Antifungals, Candida albicans, Herbal gel, Malassezia furfur