In-vitro evaluation of the thrombolytic and anti-inflammatory activity of capparis sepiaria root extracts

Moushumi Baidya, Himangshu Sekhar Maji, Shvetank Bhatt, Dibya Das

Bharat Pharmaceutical Technology, Agartala, West Tripura, India

ABSTRACT

The dried roots of Capparis sepiaria was powdered and extracted successively in soxhlet assembly. The extracts acquired had been dried after which subjected to preliminary phytochemical screening. The in vitro thrombolytic and anti-inflammatory activities of total ethanolic and aqueous extracts for Capparis sepiaria roots were performed using thrombolytic and inhibition of protein denaturation assays respectively. The preliminary phytochemical screening carried out from successive solvent extracts of Capparis sepiaria has shown the presence of carbohydrates, fixed oil, fats, alkaloids, flavonoids, tannins and phytosterols. Total aqueous and ethanol extracts were tested for clot lysis and inhibition of protein denaturation showed significant thrombolytic and anti-inflammatory activity. The total aqueous extract has shown more potential as compared to the total ethanolic extract. It can be concluded that the Thrombolytic and Anti-inflammatory properties of the total ethanolic and aqueous extracts are due to the presence of the specific phytoconstituents present in the root extracts.

Keywords:

Capparis sepiaria, Thrombolytic, Anti-inflammatory activity, Root extracts and Phytochemical screening.