Design and characterization of daunorubicin loaded solid lipid nanosuspension

N Dora Babu

College of Pharmacy, Uruk University, Baghdad, Iraq

ABSTRACT

Objective the objective of the current review was to research the conceivable utilization of strong lipid nanosuspension (SLNs) as a medication conveyance strategy to support Daunorubicin (DNR) mind focusing on execution after intranasal (I. n.) organization. Techniques: 33 factorial plans were applied for advancement by utilizing lipid fixation, surfactant focus, and High-speed homogenizer (HSH) mixing time as reliant factors, and their impact was seen on particles size, Polydispersity record (PDI), and entanglement proficiency. Results with the organization of Compritol® 888 ATO (4.6 % w/v), tween 80 (1.9 % w/v), and HSH blending time, the enhanced equation DNR-SLNs arranged (10 min). Molecule size, PDI, zeta potential, capture effectiveness, percent in vitro discharge was viewed as 167.47±6.09 nm, 0.23±0.02, 24.1 mV, 75.3±2.79, and 89.35±3.27 percent in 24 h, individually, for streamlined detailing (V-O). No significant changes in molecule size, zeta potential, and ensnaring effectiveness were found in the security learns at 4±2 °C (fridge) and 25±2 °C/60±5% RH up to 3 mo. Conclusion following the administration of non-invasive nose-brain drugs, which is a promising therapeutic strategy, the positive results confirmed the current optimized formulation of DNR-loaded SLNs.

Keywords:

Solid lipid Nanosuspension, Homogenization and Ultrasonication, Characterization, Factorial design, Nose to brain delivery.