Evaluation of in-vitro thrombolytic potential of hydroalcoholic extracts of Citrus limon leaves, Tagetes erecta flower and Musa paradisiaca stem

Padmaja Kore, Shrusti Tiwari, Charmine Richardson

Progressive Education Society’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune, India

ABSTRACT

The plants citrus Limon, Tagetes Erecta and Musa Paradisiaca are traditionally used as a remedy for the treatment of various disorders such as high blood pressure, the common cold, and irregular menstruation. Also, they are found effective in treatment of some blood disorders. The aim of present study was to investigate the in-vitro thrombolytic activity and phytochemical nature of hydroalcoholic extracts different parts of three Indian plants namely, Hydroalcoholic Extract of Citrus Limon leaves (HECL), Hydroalcoholic Extract of Musa Paradisiaca (HEMP) stem and Hydroalcoholic Extract of Tagetes erecta (HETE) flowers in their hydroalcoholic extract. Venous blood samples were drawn from 18-healthy volunteers and treated with different concentrations of plant extracts (2 mg/ml, 4 mg/ml, 6 mg/ml, 8 mg/ml, and 10 mg/ml). Streptokinase in two different concentrations i.e., 30,000 IU and 15,000 IU were used as standard. All the extracts showed the remarkable thrombolytic potential in dose dependent manner. Their remarkable effects in the present study may attract their use in various cardiovascular disorders.

Keywords:

Streptokinase, Citrus Limon, Musa Paradisiaca, Tagetes erecta, Hydroalcoholic