Design and development of fast dissolving liquisolid formulation

Bhamare Vaibhav G, Kamble Ravindra K

K. K. Wagh College of Pharmacy, Nashik, Maharashtra, India

ABSTRACT

Various techniques have been employed for the solubility modification of BCS class II drugs. Out of the recent solubility enhancement techniques, Liquisolid technique based on the work of Spireas et al has explored as method that can supplement drug release. Formulations containing Etodolac were developed by dissolving the drug in a non-volatile solvent and then employing the adsorption absorption principle with a carrier and coated material admixture. The post formulation saturation solubility study has highlighted significant modification in solubility of the drug in comparison to pre solubility modification. The Liquisolid formulation then subjected to direct compression for the development of Fast dissolving tablet formulation using two varying concentrations of Sodium Starch Glycolate. The in vitro - in vivo evaluation of research study concludes adaptability and applicability of fast dissolving liquisolid tablet formulation allowing it to overcome barriers associated with the solubility. The optimized formulation found to unveil dissolution along with diffusion from the dosage form by Fickian mechanism.

Keywords:

Etodolac, Liquisolid, Carrier material, Coating material Fast dissolving tablet, Superdisintegrant.