Synthesis and characterization of cefixime loaded silver nanoparticles for antibacterial activity against staphylococcus aureus

Padole Nitin, Avari Jasmine

Department of Pharmaceutics, Kamla Nehru College of Pharmacy, Buttibori, Nagpur, Maharashtra, India

Refer this article

Padole Nitin, Avari Jasmine, 2022. Synthesis and characterization of cefixime loaded silver nanoparticles for antibacterial activity against staphylococcus aureus. Journal of Medical Pharmaceutical and allied Science V 11 - I 5, Pages - 5246 – 5253. doi: 10.55522/jmpas.V11I5.2194.

ABSTRACT

In Recent year's medication obstruction is a quickly developing issue over the whole world in the treatment of infectious diseases. The widespread use of broad-spectrum antibiotics produced antibiotic resistance for many human bacterial pathogens. Anyways right now, nanotechnology research has been engaging more in restorative businesses with various advantages because of the way that surface area to volume proportion of Nanoparticles is quite large. In this exploration work, Silver Nanoparticles (AgNPs) are prepared by using a reducing agent like sodium borohydride and capping agent Polyvinylpyrrolidone. The prepared AgNPs and Cefixime-loaded AgNPs were subjected to characterization like particle size, FT-IR, X-ray diffraction. In addition, the AgNPs draw much interest in the account of their powerful antibacterial movement. The antibacterial activity of AgNPs and Cefixime-loaded AgNPs was checked against the bacterial culture of Staphylococcus Aureus. The zone of inhibition AgNPs was checked against microorganisms. The results of this study demonstrate the antibacterial activity of AgNPs and Cefixime-loaded Silver Nanoparticles against the bacterial culture of Staphylococcus Aureus with synergistic activity.

Keywords:

Silver Nanoparticle, Antibacterial activity, Multidrug Resistance, SEM, Antibiotics

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