Formulation and evaluation of domperidone maleate mucoadhesive system using Cassia fistula L. Seed mucilage

Dinanath T. Gaikwad, Sayali J. Patil, Suresh G. Killedar, Ganesh H. Wadkar, Dipak P. Mali, Sanjay A. Jadhav

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

Refer this article

Dinanath T Gaikwad, Sayali J Patil, Suresh G Killedar, Ganesh H Wadkar, Dipak P Mali, Sanjay A Jadhav, 2022. Formulation and evaluation of domperidone maleate mucoadhesive system using Cassia fistula l. Seed mucilage. Journal of Medical Pharmaceutical and allied Science V 11 - I 5, Pages - 5318 – 5324. Doi: 10.55522/jmpas.V11I5.4203.

ABSTRACT

Aim of the present study was to formulate and evaluate Domperidone maleate mucoadhesive system using Cassia fistula L. seed mucilage as a natural polymer. Firstly, Cassia fistula L. seed mucilage was extracted and evaluated for phytochemical screening, solubility studies, swelling index, viscosity, and surface tension. Then, domperidone maleate mucoadhesive systems were prepared with and without the Cassia fistula L. seed mucilage by direct compression method. Phytochemical screening resulted the presence of secondary metabolite especially polysaccharide in good amount. Results of hardness, friability, drug content and swelling index were satisfactory. The mucoadhesive strength of the prepared tablets can increase the residence time and eventually improve the bioavailability of the drug as evidenced from in vitro mucoadhesion strength andin vitrorelease studies. Interestingly, developed mucoadhesive system showed remarkablecontrolon there lease rate. Conclusively, the results suggest that developed domperidone maleate mucoadhesive system with Cassia fistula L. seed mucilage demonstrate interesting attributes to be explored as potential pharmaceutical mucoadhesive product.

Keywords:

Cassia fistula L., Domperidone maleate, Mucoadhesive, Natural polymer.

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