Microwave assisted synthesis of 3-substituted aryl aminochloro flouroquinoline derivatives for antimicrobial activities

Dimple Pirgal, Ramesh Jha, Shivakumar Mallappa Hipparagi

KLE College of Pharmacy, Bengaluru, Karnataka, India

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Dimple Pirgal, Ramesh Jha, Shivakumar Mallappa Hipparagi, 2022. Microwave assisted synthesis of 3-substituted aryl aminochloro flouroquinoline derivatives for antimicrobial activities. Journal of medical pharmaceutical and allied sciences, V 11 - I 6, Pages - 5461 – 5468. Doi: 10.55522/ jmpas.V11I6.3968.

ABSTRACT

Quinoline derivatives found to possess various activities such as antimicrobial, anti-tubercular, antifungal etc. 2,7-dichloro-6-fluoroquinoline-3-carbaldehyde was synthesized by treating 3-chloro-4-fluoroaniline with acetic anhydride, the intermediate (substituted acetanilide) obtained was further treated under microwave with dimethyl formamide /phosphorus oxychloride to get the desired product. Derivatives of 2,7-dichloro-6-fluoroquinoline-3- carbaldehyde [R-02] to [R-10] were synthesized by treating it with different anilines, oxindole and rhodanine. Synthesized derivatives were characterized by IR, 1HNMR and Mass spectra and evaluated for their antimicrobial properties. Antimicrobial study of these compounds shows that they have moderate activity against Gram-positive and Gram-negative strains of bacteria, but less than the standard drug (ciprofloxacin). Only [R-04] compound has slightly better activity than the standard drug (4μg/ml).

Keywords:

Anti-microbial, Ciprofloxacin, Microwave 2,7-dichloro-6-fluoroquinoline-3-carbaldehyde.

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