Susceptibility and resistance pattern of bacterial isolates and development of antibiogram in a tertiary care hospital of western India

Manoj Dikkatwar, Jitendra Vaghasiya, Firdosh Mansuri, Mukesh Nath, Madhuri Chaudhari

Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Vadodara, Gujrat, India

Refer this article

Manoj Dikkatwar, Jitendra Vaghasiya, Firdosh Mansuri, Mukesh Nath, Madhuri Chaudhari, 2023. Susceptibility and resistance pattern of bacterial isolates and development of antibiogram in a tertiary care hospital of western India. Journal of medical pharmaceutical and allied sciences, V 12 - I 1, Pages - 5504 – 5509. Doi: 10.55522/jmpas.V12I1.3987.

ABSTRACT

The main issue in India and at a global level that led to antibiotic resistance is misuse, irrational prescribing of antibiotics, and lack of sufficient data on antibiotic resistance at a local,regional, and national level to develop antibiotic policy that guides all healthcare professional while prescribing antibiotics. The present study was carried out for 12 months in a tertiary care teaching hospital in western India to develop an antibiogram and to check antimicrobial resistance trends in the hospital. Out of 500 patients, 53.6% were male and 46.4% were female patients. A total of 17 bacterial species were identified throughout the study with gram-negative species infections being most common in hospitals. Escherichia coli was the most frequently isolated gram-negative species. Ceftriaxone was most prescribed frequently followed by amoxicillin and azithromycin, respectively. In the gram-positive organism, ceftriaxone and amoxicillin resistance rate was 65.35% and 35% respectively. Overall, in the study Cceftriaxone (58%) and amoxicillin-clavulanic acid (38.9%), Azithromycin (56%), and ciprofloxacin (53%) were found most resistant antibiotics, and Amikacin (72%), Clindamycin (18%) were most sensitive. Gram-negative infections were identified mostly and cephalosporine and fluoroquinolones antibiotics were showing high antibiotic resistance. An institutional hospital antibiogram was developed to check local antimicrobial agents for various bacteria.

Keywords:

Anti-biogram, Anti-biotics, Anti-microbial stewardship program, Anti-biotic policy, Culture, Sensitivity test.

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