Nano-suspension loaded mucoadhesive mouth dissolving film of meclizine hydrochloride

Vinayak Shivamurthi Mastiholimath*, Sujit Prabhu Khope, Pallavi Raosaheb Chiprikar, Anand Shripal Ammanage, Umeshkumar Dinesh Patel

Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, India

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Vinayak Shivamurthi Mastiholimath, Sujit Prabhu Khope, Pallavi Raosaheb Chiprikar, Anand Shripal Ammanage, Umeshkumar Dinesh Patel, 2023. Nano-suspension loaded mucoadhesive mouth dissolving film of meclizine hydrochloride. Journal of medical pharmaceutical and allied sciences, V 12 - I 3, Pages - 5874 – 5884. Doi: Doi: 10.55522/jmpas.V12I3.5037.

ABSTRACT

Meclizine Hydrochloride belongs to class H1 antagonist, antiemetic and anti-vertigo in nature, it is a Biopharmaceutical classification system (BCS) class II drug and is practically insoluble in water. The bottom-up approach was used in the formulation of nanosuspension in which methanol and millipore water was used as solvent and anti-solvent respectively, the stabilizers used for preparation were Polyvinylpyrrolidone K30 (PVP K30) and Hydroxypropyl Methylcellulose E15 (HPMC E15) which were found to be compatible with the formulation after Fourier Transform Infrared (FTIR) and Differential scanning calorimeter (DSC) studies. Mouth dissolving films were formulated by solvent casting method using glycerine lubricated petri dish and were kept for heating in a hot air oven at 45°C overnight. Characterization of nanosuspension-loaded mucoadhesive mouth dissolving films was done by evaluating various characteristics, the highest drug content was found to be 92.43±0.49% in Mouth dissolving film (MDF) 2. In-vitro drug release studies indicate that nanosuspension-loaded mucoadhesive mouth-dissolving film has a rapid drug release rate as compared to plain drug-loaded mouth-dissolving films and marketed tablet formulation.

Keywords:

Nanosuspension, Meclizine Hydrochloride, Solvent casting, Mouth dissolving film

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