Design synthesis in-silico study and biological evaluation of quinoline derivatives as potential antibacterial agents

Vinod Kumar Gurjar, Dodiya Raj Mukeshbhai, Kushwaha Raju, Subhash Devanshi Parekh

School of Pharmacy, Faculty of Pharmacy, Parul University, Vadodara, Gujarat, India

Refer this article

Vinod Kumar Gurjar, Dodiya Raj Mukeshbhai, Kushwaha Raju, Subhash Devanshi Parekh, 2023. Design synthesis in silico study and biological evaluation of quinoline derivatives as potential antibacterial agents, V 12 - I 4, Pages - 6001 – 6011. Doi: https://doi.org/10.55522/jmpas.V12I4.5080.

ABSTRACT

The purpose of this article is to synthesize some novel quinoline-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help of elemental analysis, IR, NMR, and mass spectral data, the synthesized derivatives were identified. Derivatives' antibacterial activity was determined using the cup and plate diffusion method. At doses of 50 μg/ml and 100 μg/ml, the substance demonstrated substantial antibacterial potential against the tested strains. To predict the pharmacokinetic properties (ADME) of these derivatives, in-silico investigations were also carried out. For the current study, the in silico Swiss ADME-assisted results were shown to be suitable for the derivation and synthesis of efficient antibacterial drugs.

Keywords:

ADMET, Quinoline, Ciprofloxacin, Antimicrobial.

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