A retrospective study on comparison of effects of older art regimen against Dolutegravir based art in PL-HIV

B S B Mallika, Silla Jyothi Prakash, Kaniganti Sri Rahitya, Pilla S Surya Durga Devi, K V SivaPrasad K

Rangaraya medical college, Kakinada, Andhra Pradesh, India

Refer this article

B S B Mallika, Silla Jyothi Prakash, Kaniganti Sri Rahitya, Pilla S Surya Durga Devi, K V Siva Prasad, 2023. A retrospective study on comparison of effects of older art regimen against Dolutegravir based art in PL-HIV. Journal of medical pharmaceutical and allied sciences, V 12 - I 5, Pages - 6142 – 6146. Doi: https://doi.org/10.55522/jmpas.V12I5.5138.

ABSTRACT

According to the WHO guidelines 2020, Dolutegravir-based antiretroviral treatment (ART) is a preferred first-line ART regimen for people living with HIV (PLHIV) because of its efficacy, tolerance, high barrier to resistance, and minimal drug interactions. The main aim of this study is to assess the safety and efficacy of a Dolutegravir based antiretroviral therapy regimen to that of older regimens. A retrospective observational study was conducted among the people who visited the ART center on an Out-Patient basis. One to One interview was taken with the patients who met the inclusion criteria and all the information was noted down in the demographic form. Adverse Drug Reactions were noted in the Suspected Adverse Drug Reaction (ADR) Form and then we assessed causality, severity, and Prevent-ability. All the data was entered into an excel sheet and analyzed using SPSS21 software. Out of the study population of 100, 63% are females and 36% are males. The paired T-test sampling statistics revealed a significant difference between an increase in CD4 count after transitioning to a Dolutegravir-based regimen in comparison with the older regimens (p<0>

Keywords:

Antiretroviral therapy, Dolutegravir, Dolutegravir transition, Adverse Drug Reactions.

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