Evaluation of the results of treatment of primary knee osteoarthritis using intra-joint synolis VA injection

Tran Trong Duong, Tran Thai Phuc*, Park Sung Jong, Vu Hai Nam

Faculty of Nursing, Thai Binh University of Medicine and Pharmacy, Vietnam

Refer this article

Tran Trong Duong, Tran Thai Phuc, Park Sung Jong, Vu Hai Nam, 2024. Evaluation of the results of treatment of primary knee osteoarthritis using intra-joint synolis VA injection. Journal of medical pharmaceutical and allied sciences. V 13 - I 3, Pages - 6570 – 6574. Doi: https://doi.org/10.55522/jmpas.V13I3.6466

ABSTRACT

Evaluate the results and unwanted effects of intra-articular injection therapy of hyaluronic acid combined with sorbitol in the treatment of primary knee osteoarthritis. Subjects and methods: Prospective, interventional, controlled study with longitudinal follow-up on 101 patients with 151 knee osteoarthritis stages II and III according to Kellgren and Lawrence, divided into 2 groups: intervention group. Inject 1 tube of Synolis VA 80/160mg into the damaged knee joint, the control group was treated with oral medications Mobic, Viatril S. VAS, WOMAC scores, knee flexion amplitude in the intervention group improved significantly starting from week 4 and continued until week 12, statistically significantly better than the control group (p< 0.01). After 12 weeks of treatment, the VAS score decreased from 5.28 to 1.24, the rate of moderate/severe pain decreased from 100% to 6.8%, 39.2% had no pain, the overall WOMAC score decreased from 36.46. down to 12.27, the knee joint flexion amplitude increased by 19.46 ± 11.84 degrees, the rate of satisfaction and very satisfaction was 92.3% (p<0.01). No serious unwanted effects were encountered, 28.4% of knee joint tightness after injection, 12.2% of post-injection pain within 12-24 hours, 4.1% of joint effusion. Conclusion: Intra-articular injection therapy of hyaluronic acid combined with sorbitol has a fast pain relief effect, improves knee joint mobility better than the control group and is safe.

Keywords:

Primary Knee Osteoarthritis, Synolis VA, Hyaluronic Acid, Sorbitol

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