The combined effect of medicinal plant extract and sulfonylurea agent: a preliminary study to evaluate anti-diabetic potential in experimental animals

Sunny Desai, Vaishali Thakkar*, Tejal Gandhi

Gujarat Technological University, Anand Pharmacy College, Department of Pharmaceutics, Anand, Gujarat, India

Refer this article

Sunny Desai, Vaishali Thakkar, Tejal Gandhi, 2024. The combined effect of medicinal plant extract and sulfonylurea agent: a preliminary study to evaluate anti-diabetic potential in experimental animals. Journal of medical pharmaceutical and allied sciences, V 13 - I 6, Pages - 6847 – 6854. Doi: https://doi.org/10.55522/jmpas.V13I6.6798.

ABSTRACT

Chronic metabolic diseases like diabetes mellitus have a huge terrible effect on a society's health and monetary system. because there are various issues with the treatment this is now available. it is important to search for trade remedies. A aggregate of natural and allopathic remedy can be an effective remedy as an possibility to available treatment. therefore, the purpose of this take a look at have turn out to be to take a look at the combination anti-diabetic outcomes of Glibenclamide and “aloe vera” extract in experimental animals. The antihyperglycemic pastime turned into assessed using an oral glucose tolerance take a look at and diabetes brought about using manner of the use of streptozotocin (STZ) & excessive fat weight loss plan (HFD) version in rats. Wister rats were divided into 5 organizations. business enterprise I was dealt with with a normal pallet diet regime. group II come to be given HFD and streptozotocin. employer III has come to be given HFD &Streptozotocin and treated with Glibenclamide. organization IV was modified into given HFD & Streptozotocin and dealt with with “aloe vera” extract. agency V modified into given HFD & Streptozotocin and handled with a way containing “aloe vera” extract and Glibenclamide. Physiological parameters which incorporate body weight and biochemical parameters consisting of blood glucose, HbA1c level, lipid profiles, and oxidative strain parameters collectively with glutathione (GSH) & malondialdehyde (MDA) degree were used to assess the antidiabetic potential of a method containing “aloe vera” extract and glibenclamide. approach containing “aloe vera” extract and Glibenclamide. device containing “aloe vera” extract and Glibenclamide has a good-sized effect in controlling blood glucose ranges. lower in HbA1c degree, and lipid profiles (besides HDL stage)verify effective anti-diabetic remedy of the test system. similarly, massive adjustments in GSH & MDA tiers propose a functionality synergistic anti-oxidant impact of the mixed remedy. the existing take a look at observed out that a technique containing “aloe vera” extract and Glibenclamide confirmed a good sized antidiabetic ability, via the reversing of hyperlipidemia, and oxidative pressure fame in non-diabetic & diabetes rats.

Keywords:

Diabetes mellitus, High Fat Diet, Streptozotocin, “Aloe vera” Glibenclamide

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