Microspheres: a novel drug delivery approach

Rupajit Bhattacharjee, Kuntal Manna*, Sinha Ashutosh Kumar

Department of Pharmacy, Tripura University (A Central University), Agartala, Tripura, India

Refer this article

Rupajit Bhattacharjee, Kuntal Manna, Sinha Ashutosh Kumar, 2025. Microspheres: a novel drug delivery approach. Journal of medical pharmaceutical and allied sciences, V 14 - I 2, Pages - 42 – 54. Doi: https://doi.org/10.55522/jmpas.V14I2.6841.

ABSTRACT

Advancements in biotechnology, genetics, and combinatorial chemistry are facilitating the development of a diverse array of novel, more effective and targeted therapies. The efficacy and commercialization potential of many new medications can be significantly influenced by drug delivery methods due to prevalent issues such limited solubility, high potency, and/or poor stability. Consequently, there is a want for safer and more efficient medication delivery systems and equipment. Drug delivery systems are engineered to administer a therapeutic agent in the requisite dosage, at the appropriate time, to the correct site within the body, thereby enhancing efficacy, improving compliance, and reducing side effects. Microspheres are typically free-flowing powders composed of proteins or biodegradable synthetic polymers, with an optimal particle size of less than 1000 µm. An effectively designed controlled drug delivery system can address some issues associated with conventional therapy and improve the therapeutic efficacy of a certain medicine. Multiple methodologies exist for administering a therapeutic agent to the target location in a sustained and controlled release manner. One method involves utilizing microspheres as medication carriers.

Keywords:

Microspheres, Classifications of microspheres, Synthesis, Characterization, Applications.

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