Therapeutic potential of Raphanus sativus var. L ethyl acetate fraction in hyperlipidemic and hyperglycemic wistar rats (Rattus norvegicus)

Dwintha Lestari*, Maulidwina Bethasari, Zulkaida, Ahmad Nur Alif, Meuthia Alika Faza, Gofarana Wilar

Department of Pharmacy Universitas Muhammadiyah Bandung, West Java, Indonesia

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Dwintha Lestari, Maulidwina Bethasari, Zulkaida, Ahmad Nur Alif, Meuthia Alika Faza, Gofarana Wilar, 2025. Therapeutic potential of Raphanus sativus var. L ethyl acetate fraction in hyperlipidemic and hyperglycemic wistar rats (Rattus norvegicus). Journal of medical pharmaceutical and allied sciences, V 14 - I 3, Pages - 39 – 44. Doi: https://doi.org/10.55522/jmpas.V14I3.6903

ABSTRACT

Cardiovascular diseases (CVD), primarily driven by hyperlipidemia and hyperglycemia, represent a significant global health burden. Effective treatments for these conditions are often inaccessible, particularly in low-income populations, which underscores the importance of exploring alternative therapeutic approaches. This study investigates the anti-hyperlipidemic and anti-hyperglycemic effects of the ethyl acetate fraction from Raphanus sativus var. L. (white radish) in male Wistar rats. The fraction demonstrated significant cholesterol-lowering effects, reducing total serum cholesterol levels in hyperlipidemic rats from 216.4 ± 8.08 mg/dl to 110 ± 4.89 mg/dl. Additionally, it lowered blood glucose levels in hyperglycemic rats from 446.6 ± 46.19 mg/dl to 335 ± 69.31 mg/dl. These findings suggest that white radish extract, particularly the ethyl acetate fraction, holds potential as a natural therapeutic agent for managing hyperlipidemia and hyperglycemia.

Keywords:

Anti-hypercholesterol, Anti-hyperglycaemic, Ethyl acetate fraction, Raphanus sativus var. L.

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