Synthesis & characterization of 4- hydroxyacetanilide starting from acetanilide

Aditya Dixit*, Pramod Kumar Sharma

Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Yamuna Expressway, Gautam Budh Nagar, Uttar Pradesh, India

Refer this article

Aditya Dixit, Pramod Kumar Sharma, 2016. Synthesis & characterization of 4- hydroxyacetanilide starting from acetanilide. Journal of medical pharmaceutical and allied sciences, V 5 - I 2, Pages -308 – 309. Doi: https://doi.org/10.55522/jmpas.V5I2.0080.

ABSTRACT

This research deal with the new way of synthesizing paracetamol because traditional method is not suitable in general conditions and acetic anhydride is not readily available in the present scenario. In the first step the acetanilide was nitrated with nitric acid in the presesnce of sulphuric acid to form p-Nitroacetanilide, and then it was reduced to p-Amino derivative, then it was converted to diazonium salt. In the final step the diazonium salt was treated with 10% NaOH solution. Final compound was washed with water and recrystallized from ethanol. Products were characterized by melting point and FTIR. This method gives 80% yield.

Keywords:

Crude, Characterization, FTIR, Gliflozins,

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