Evaluation of toxicological effects of contaminated gentamicin injection on liver enzymes of juvenile Wistar rats

I A Takon, S P Antai, E U Eyong

Department of Microbiology, University of Calabar, Nigeria

Refer this article

I A Takon, S P Antai, E U Eyong, 2016. Evaluation of toxicological effects of contaminated gentamicin injection on liver enzymes of juvenile Wistar rats. Journal of medical pharmaceutical and allied sciences, V 5 - I 2, Pages -325 – 328. Doi: https://doi.org/10.55522/jmpas.V5I2.0085.

ABSTRACT

The toxicological effects of contaminated gentamicin injections obtained from patent medicine stores on the liver enzymes of wistar rats after intramuscular administration have been investigated. Six (6) adult wistar rats weighing between 100g-250g were used. These animals were kept two (2) per cage/group (A, B, and C), where group A was fed with 0.1mL water for injection, and also served as control. Groups B and C were the experimental groups and administered 58mg of gentamicin injection intramuscularly per rat/day at 6hr divided doses twice daily for 5 days. The effects of contaminated gentamicin injection on levels of serum parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes were compared with control. The level of ALP was significantly high in the experimental groups (B and C) at P<0>

Keywords:

Gentamicin injection, Liver enzymes, wistar rats, contamination.

Full Text Article