Effect GC-MS Analysis and Antimicrobial Activity of Sudanese Cucumis melo L. (Cucrbitaceae) Fixed Oil

Abdel Karim M*, Asma H, Kamal M S

Department of Chemistry, Faculty of Science Sudan University of Science and Technology, Sudan

Refer this article

Abdel Karim M, Asma H, Kamal M S, 2016 Effect GC-MS Analysis and Antimicrobial Activity of Sudanese Cucumis melo L. (Cucrbitaceae) Fixed Oil. Journal of Medical, Pharmaceutical, and Allied Sciences, V 5 - I 6, Pages -425 – 427. Doi: https://doi.org/10.55522/jmpas.V5I6.0112.

ABSTRACT

The present study was designed to investigate the chemical constituents of Sudanese Cucumis melo seed oil and to evaluate its potential antimicrobial activity. 28 components were detected by GC-MS analysis. Major constituents are: methyl 10-trans,12-cis-octadecadienoate (49.28%) , 9-octadecenoic acid methyl ester(19.40%) , hexadecanoic acid methyl ester(15.92%) , methyl stearate(11.22%). The antimicrobial activity of the oil was evaluated via cup plate agar diffusion bioassay against six standard human pathogens (Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative : Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger) . The oil showed different antimicrobial responses against test organisms. It gave significant activity against the fungus: Candida albicans and partial activity against Staphylococcus aureus.It seems that the oil is a lead for further optimization.

Keywords:

Cucumis melo, Fixed oil, Cucumis melo, Fixed oil, activity.

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