Therapeutic values of Simarouba glauca with reference to its anticancer potentiality

Md Ikbal Husain, Biplab De*

Regional Institute of Pharmaceutical Science and Technology (RIPSAT), Abhoynagar, Tripura, India

Refer this article

Md Ikbal Husain, Biplab De, 2026. Therapeutic values of Simarouba glauca with reference to its anticancer potentiality. Journal of medical pharmaceutical and allied sciences, V 15, I 3, Pages 65 – 70. Doi: https://doi.org/10.55522/jmpas.V15I3.7086.

ABSTRACT

Simarouba glauca, commonly known as Paradise Tree, has sparked considerable scientific attention due to its diverse phytochemical profile and potential medicinal uses. Traditionally it was used in many cultures to cure maladies such as malaria, diarrhoea and inflammatory disorders. Contemporary studies have focused on its anticancer potential, which is supported by a varied array of bioactive ingredients such as quassinoids, alkaloids and triterpenoids. Our review includes a wide range of pharmacological evidence, particularly in vitro and in vivo studies, that highlight its antiproliferative, apoptotic and immunomodulatory actions in a variety of cancer models, including breast, prostate, lung, ovary and leukaemia. Furthermore, the safety profile of its leaf and seed oil extracts has been investigated in a number of toxicity studies, all of which indicate a wide margin of safety. Despite these encouraging findings, we recognise many limitations, including a lack of standardised formulations, clinical data and sophisticated drug delivery methods. In this review, we emphasise the importance of future pharmacokinetic investigations, formulation development and clinical trials to convert Simarouba glauca from a traditional treatment to a proven anticancer therapy.

Keywords:

Anticancer activity, Quassinoids, Simarouba glauca, Traditional medicine.

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