A SHORT COMMUNICATION ON THERAPEUTIC IMPORTANCE OF siRNA INDUCED GENE SILENCING

Malik Vivek Singh, Vyas Swati, Sharma Purnendu Kumar

ABSTRACT

Small interfering ribonucleic acid (siRNAs) are small interfering molecules which are messenger ribonucleic acid (mRNA) specific have many potential therapeutic role and by approaching techniques like microarray make possible of genome wide study. Small Interfering RNA have short 20-24 bp double stranded deoxyribonucleic acid (dsDNA) with phosphorylated 5’ ends and hydroxylated 3’ ends with two overhanging nucleotides. siRNA can also be introduced by transfection. Introduction of too much small interfering ribonucleic acid (siRNA) can results in nonspecific events due to activation of innate immune response.

Keywords: siRNA, microarray, helicase, mRNA, therapeutic.