FORMULATION AND EVALUATION OF IN -SITU OCULAR DRUG DELIVERY SYSTEM OF GENTAMICIN SULPHATE

Gupta V.V., Namdev Ashish*, Agarwal K.L.

Nri institute of pharmaceutical science Bhopal (m.p.) India

ABSTRACT

Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. The conventional ocular drug delivery systems like solutions, suspensions and ointments show drawbacks such as increased pre-corneal elimination, high variability in efficiency and blurred vision respectively. Each system has its own advantages and disadvantages.This research includes temperature and pH induced in situ-forming polymeric systems used to achieve prolonged contact time of drugs with the cornea and increase their bioavailability. Ophthalmic In-situ gels are viscous polymer‐based liquids that exhibit sol‐to‐gel phase transition on the ocular surface due to change in a specific physicochemical parameter like ionic strength, pH or temperature. Gel dosage forms are successfully used as drug delivery systems considering their ability to prolong the drug release. In-Situ gel were evaluated for clarity, pH measurement, gelling capacity, drug content estimation, rheological study, in vitro diffusion study and ICH stability studies. The developed formulations exhibited sustained release of drug over a period of 8 hours thus increasing residence time of the drug and optimized formulations also found satisfactorily stable, thus these in situ gelling systems may be a valuable alternative to the conventional systems.

Keywords: Ophthalmic in situ gel, Gentamicin Sulphate, PluronicF127, carbopol.