Research article- CO-PROCESSED SUPERDISINTEGRANT A NOVEL APPROACH FOR REDUCING RISK IN DOSAGE FORM FORMULATION

Pitliya Prateek *, Saini Pramod, Garg Shiv K, Pareek Ajay K

ABSTRACT

Several advantages offered by co-processed excipients such as production of synergism in functionality of individual components, reduction of company’s regulatory concern because of absence of chemical change during co-processing and improvement in physico-chemical . The current review article is prepared to have a look over the recent development in excipient, co – processed excipients especially superdisintegrants and its composition & application for tablet manufacturing. With the ongoing demand of novel drug delivery, the Mouth dissolving tablet /sublingual /fast dissolving drug delivery system has become one of the mile stone of present research. There are many superdisintegrants, like polyplasdone, Sodium starch glycolate , kollidone CL, kollidone CLF, kollidone CL-SF, kollidone CL-M, starch 1500, etc. The search for newer disintegrating agent is ongoing and researcher are experimenting with multifunctional superdisintegrants due to its better disintegration, compact ability , mouth feel & flow property. Co-processed excipients especially superdisintegrants are reduce risk in early dosage form formulation due to its multifunctional property.

Keywords: Co- processed excipients, Superdisintegrants, Kollidon, pearlitol.