SYNTHESIS & CHARACTERIZATION OF 4-HYDROXYACETANILIDE STARTING FROM ACETANILIDE

DIXIT ADITYA* and SHARMA PRAMOD KUMAR

Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University Yamuna Expressway, Gautam Budh nagar, U.P., India

ABSTRACT

This research deal with the new way of synthesizing paracetamol because traditional method is not suitable in general conditions and acetic anhydride is not readily available in the present scenario. In the first step the acetanilide was nitrated with nitric acid in the presesnce of sulphuric acid to form p-Nitroacetanilide, and then it was reduced to p-Amino derivative, then it was converted to diazonium salt. In the final step the diazonium salt was treated with 10% NaOH solution. Final compound was washed with water and recrystallized from ethanol. Products were characterized by melting point and FTIR. This method gives 80% yield.

Keywords: Crude, Characterization, FTIR, Gliflozins