Role of Cytokines in Pathogenesis of Rheumatoid Arthritis-A Review

Hem Raj Vashist, Avneet Gupta, Neeraj upmanyu

1- Department of pharmacy CMJ University Jorabat, Rai Bhoi, Meghalaya India.-793001. 

ABSTRACT

Introduction-Cytokines are polypeptides autacoids produced by phagocytes and some other cells. A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA). It has been evidently proved that cytokines play fundamental role in bone reabsorption and connective tissue destruction and also in complications associated with RA. Aim-By knowing the sinister role of cytokines to induce rheumatoid arthritis in patient, the present study is focused on the review of different cytokines which involve in the pathogenesis of the disease. Result-From the literature available from different article on cytokines it is clear that cytokines like Tumor necrosis factor (TNF-α), chemokines and Interleukins (IL) are responsible for the pathogenesis of rheumatoid arthritis. Conclusion-from the previous literature it was concluded that Cytokines are responsible for the pathogenesis of rheumatoid arthritis. Safe intervention can be evaluated by understanding this fact.

Keywords: Cytokines, Polypeptides, Autacoids, Rheumatoid Arthritis, Bone Reabsorption, Tissue Destruction.