Comparative Analgesic and Antipyretic activity of ethanolic extract of Tragia plukenetii

Kalaivanan M., L. Louis Jesudoss, A. Saravana Ganthi and M. Padma Sorna Subramanian

1. Department of Pharmacology, Govt. Siddha Medical College, Palayamkottai, Tamil Nadu 2. Department of Botany, St. Xavier’s College, Palayamkottai, Tamil Nadu 3. Department of Botany, Rani Anna Govt. College for Women, Tirunelveli, Tamil Nadu. 4. Siddha Medicinal Plants Garden, CCRS, Mettur Dam, Tamil Nadu

ABSTRACT

The present study investigates the analgesic and antipyretic activity of ethanolic extract of Tragia plukenetii, is a valuable medicinal plant. Phytochemical analysis of Tragia plukenetii plant extracts revealed the presence of various bio-chemical compounds such as flavonoids, glycosides, alkaloids, saponins and terpenoids. Since flavonoids have remarkable analgesic activity, the present work aims at evaluating the invivo analgesic activity of Tragia involucrata by acetic-acid induced writhing response method and Eddy’s hot plate method. Brewer’s yeast induced hyperpyrexia method was used for antipyretic activity study. The data of the present studies suggests that T. plukenetii extract showed significant anti-pyretic and analgesic activity. Therefore the present studies support the isolation and use of active constituents of Tragia in treating pain.

Keywords: Tragia plukenetii, flavanoids, analgesic activity, antipyretic activity.