DR DIBYAJYOTI SAHOO, DR SMITA MAHAPATRA, DR RAJIV KUMAR NAYAK, DR DEBASISH MISHRA

DOI:

VOLUME-5, ISSUE-12

A RARE CASE OF THALASSEMIA INTERMEDIA WITH MULTIPLE ALLOANTIBODIES

DR DIBYAJYOTI SAHOO, DR SMITA MAHAPATRA, DR RAJIV KUMAR NAYAK, DR DEBASISH MISHRA

1. SENIOR RESIDENT, DEPARTMENT OF TRANSFUSION MEDICINE, AIIMS, BHUBANESWAR, ODISHA, INDIA

2. ASSOCIATE PROFESSOR, DEPARTMENT OF TRANSFUSION MEDICINE, SCB MEDICAL COLLEGE, CUTTACK, ODISHA, INDIA

3. ASSISTANT PROFESSOR, DEPARTMENT OF CLINICAL HEMATOLOGY, SCB MEDICAL COLLEGE, CUTTACK, ODISHA, INDIA

4. JUNIOR RESIDENT, DEPARTMENT OF TRANSFUSION MEDICINE, SCB MEDICAL COLLEGE, CUTTACK, ODISHA, INDIA

ABSTRACT

Presence of anti red cell antibodies remains a major problem in Thalassemia patients. Beta-Thalassemia major patients do commonly suffer from alloimmunization which is rarely seen in Thalassemia intermedia patients. Association of multiple antibodies and antibody against high frequency blood group antigen further complicates the transfusion therapy. Advance immunohematological tests like adsorption, elution, and phenotyping are necessary along with antibody typing and identification. The present case is a 24 year male Thalassemia intermedia patient, whose blood sample when cross matched found incompatible with more than 100 units of PRBC. Various tests like DCT, ICT, 3 cell panel, 4 cell panel, 10, 11, 16 cell panels, adsorption, elution, minor phenotyping were done to resolve the case. We found multiple alloantibodies with no autoantibody. The present case emphasises on importance of minor phenotyping before first transfusion in all multitransfused patients, and importance of immunohematological tests in resolving blood incompatibility.

Keywords: Alloimmunization, phenotyping, adsorption, elution

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