SMART THERAPEUTIC ANTIDYSLIPIDEMIC NATURE OF POLICOSANOL IN MINIMAL DOSING LEVEL

Madhav n.v.satheesh 1, Reddy gopu bala 2, Khan abu rafey2, Singhal manmohan 1, Rana vijay singh 1, Varshney sugandha 1, Raina deepika 1

Faculty of Pharmacy, DIT University, Dehradun, India

ABSTRACT

Policosanol is a mixture of higher aliphatic primary alcohol extracted from sugar cane wax with hypolipidemic activity. It protects cardiovascular morbidity. This study was conducted to determine Antihyperlipidemic activity of Policosanol in Albino Rats (Rattus norvegicus) at low dose levels. Hyperlipidemia was induced in rats (by Triton) then Antihyperlipidemic activity of Policosanol was observed. Animals were divided into 6 Groups, Vehicle Control (Hyperlipidemic animals treated with Distilled Water as Vehicle), Standard Simvastatin (10mg) Simlep-FC cipla, 1mg/kg, 5mg/kg, 10mg/kg, 20mg/kg Policosanol Test Groups and doses were given accordingly. In-Vitro, In-Vivo study was conducted on experimental animals and estimated Total Cholesterol and HDL Cholesterol Concentrations. Results were compared with that of Simvastatin. Policosanol showed significant reduction in Cholesterol level in Triton X-100 LR grade induced Hyperlipidemic Albino Rats and results were comparable to group of animals treated with Standard Simvastatin 10mg. It was concluded that Policosanol (1mg/kg) was optimum dose for Hypocholesteremic activity above or below which dose may cause variation in response. Results revealed that Policosanol showed significant reduction in Cholesterol level in triton induced Hyperlipidemia animals and results were comparable to the Standard Simvastatin.

Keywords:

Hypolipidemic activity, Policosanol, Simvastatin, Triton.>>