Single Domain Antibodies: A New Approach in Therapeutics

Narkhede Mahesh *, Narkhede Rohan, Mapari Mangesh

Department of Pharmacology, Dr. Rajendra Gode College of Pharmacy, Malkapur-maharastra, India

ABSTRACT

Single domain antibodies are rapidly comes into therapeutics in last two decades due to their therapeutic advantages. Most of drugs are derived from antibodies based proteins. Single domain antibodies having advantages over the monoclonal antibodies such as small size, heat resistant, stability, hydrophobicity, low immunogenicity, high solubility. These are small in size hence called nobodies. Their production is carried outing mammalian cells for therapeutic uses. These single domain antibodies are now employed in drug delivery system. They are also utilized in identification of toxin. Single domain antibodies are recently employed in treatment diseases like cancer, Alzheimer’s disease, Parkinson’s disease etc. They are also employed in virus detection.

Keywords:

Single domain antibodies, Nano bodies, Polymer some, Complementarity, ADCC, Multimerization.