RADIOSURGERY TREATMENT VOLUME DETERMINATION FOR BRAIN LYMPHOMAS WITH AND WITHOUT INCORPORATION OF MULTIMODALITY IMAGING

Omer Sager*, Ferrat Dincoglan, Selcuk Demiral, Murat Beyzadeoglu

University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey

ABSTRACT

Primary Central System Lymphoma (PCNSL) constitutes an infrequent type of extra nodal non-Hodgkin lymphoma (NHL). While RT may be included in management of brain lymphomas to improve treatment outcomes, radiation induced toxicity and deterioration of overall health has been an important concern. In this original research article, we evaluate the incorporation of Magnetic Resonance Imaging (MRI) for treatment planning of brain lymphomas. Radiation treatment volume determination based on incorporation of MRI or based on CT-simulation images only was comparatively evaluated for patients with CNS lymphoma in our study. Ground truth target volume used as reference for comparison purposes was outlined by the expert team of radiation oncologists after colleague peer review, collaboration, and consensus. Treatment volume determination by CT-only imaging and by CT-MR fusion based imaging was assessed. Ground truth target volume outlined by the expert team of radiation oncologists after thorough assessment, collaboration, colleague peer review and consensus has been found to be similar with CT-MR fusion based treatment volume determination.

Keywords:

Primary Central System Lymphoma (PCNSL), radio surgery, brain lymphoma, magnetic resonance imaging (MRI)